The Research Report provides a comprehensive, in-depth analysis of the key challenges faced by micro, small, and medium enterprises (MSMEs) in adopting and implementing Environmental, Social, and Governance (ESG) principles. The report examines barriers such as limited resources, knowledge gaps, and supply chain complexities, and will offer practical, actionable solutions to enhance ESG integration across diverse APEC economies. It is intended to serve as a valuable knowledge resource for policymakers, business leaders, and other stakeholders seeking to promote sustainable business practices and improve MSME participation in responsible supply chains.