This report presents the results of a workshop held in Honolulu, Hawaii in May 2019 with nine APEC economies to discuss the interdependencies of energy and water in energy development and natural resource sustainability.  The goal of the workshop was to solicit input from APEC economies on their emerging energy-water-climate-food challenges, and help identify the major science, technology, and modeling and analysis needs of APEC economies to help integrate energy-water nexus planning and policies in the future to improve energy and economic development reliability and resiliency. The report highlights the major challenges and needs identified by the participants.